Michelle Pfeiffer:Melanie Parker;George Clooney:Jack Taylor;Mae Whitman:Maggie Taylor;Alex D. Linz:Sammy Parker;Charles Durning:Lew;Jon Robin Baitz:Mr. Yates, Jr.;Ellen Greene:Mrs. Elaine Lieberman;Joe Grifasi:Manny Feldstein;Pete Hamill:Frank Burroughs;Anna Maria Horsford:Evelyn;Gregory Jbara:Freddy;Sheila Kelley:Kristen;Bitty Schram:Marla;Barry Kivel:Mr. Yates, Sr.;Robert Klein:Dr. Martin;George Martin:Mr. Smith Leland;Michael Massee:Eddie Parker;Amanda Peet:Celia;Holland Taylor:Rita;Rachel York:Liza;Marianne Muellerleile:Ruta;Steven Jang:Vincent Wang;Samantha Cintrón:Rosa Lopez;Victor Truro:Sammy's Pediatrician;Ashley Greenfield:Jessica;Sidney Armus:Mayor Sidney Aikens;Hal Panchansky:Metro Reporter;Maggie Wagner:Daily News Reporter;Isabelle Ashland:Daily News Reporter;Jasmin Hartmann:Daily News Reporter;Larry Sherman:Daily News Visitor;Shaun Duke:Foreign Artist Guy;Thomas Schall:Gentleman;Michael Badalucco:Lt. Bonomo;Jeanie Van Dam:Old Woman;Kirstin Allen:Pregnant Saleslady;Michael Genet:Mayor Aikens' Press Secretary;Julia Ryder Perce:Lew's Secretary;P.J. Aliseo:Spiderman;Liam Ahern:The Incredible Hulk;José Rabelo:Museum Guard;Darla Hill:Oribe's Receptionist;Joe Avellar:Reporter;Jullie Chung:Reporter;Dale Kasman:Lady in the Police Station;Andrew Magarian:Bum in the Police Station;Katherine Argo:Passerby #1;Rob Kelly-Buntzen:Passerby #2;Brian Cahill:Passerby #3;Fred Goehner:Davis;Kuniko Narai:Flower Shop Employee