Anne Hathaway:Andrea 'Andy' Sachs;Meryl Streep:Miranda Priestly;Emily Blunt:Emily Charlton;Stanley Tucci:Nigel Kipling;Simon Baker:Christian Thompson;Adrian Grenier:Nate Cooper;Tracie Thoms:Lily;Rich Sommer:Doug;Daniel Sunjata:James Holt;David Marshall Grant:Richard Sachs;Rebecca Mader:Jocelyn;Gisele Bündchen:Serena;Heidi Klum:Herself;Alyssa Sutherland:Clacker;Ines Rivero:Clacker in Elevator;Stephanie Szostak:Jacqueline Follet;Ivanka Trump:Herself;Tibor Feldman:Irv Ravitz;James Naughton:Stephen;Colleen Dengel:Caroline Priestly;Suzanne Dengel:Cassidy Priestly;Valentino Garavani:Himself;Bridget Hall:Herself;Jennifer Perito:Voice Actor