John Candy:Harry Crumb;Jeffrey Jones:Eliot Draisen;Annie Potts:Helen Downing;Tim Thomerson:Vince Barnes;Barry Corbin:P.J. Downing;Shawnee Smith:Nikki Downing;Valri Bromfield:Detective Casey;Doug Steckler:Dwayne;Renée Coleman:Jennifer Downing;Tamsin Kelsey:Marie;Joe Flaherty:Doorman;Michele Goodger:Mrs. MacIntyre;James Belushi:Man on Bus;Wesley Mann:Tim;Garwin Sanford:Dennis Kimball