Matt Dillon:Robert 'Bob' Hughes;Kelly Lynch:Dianne;James Le Gros:Rick;Heather Graham:Nadine;Eric Hull:Druggist;Max Perlich:David;James Remar:Gentry;John Kelly:Cop;Grace Zabriskie:Mrs. Hughes;George Catalano:Trousinski;Janet Baumhover:Neighbor Lady;Ted D'Arms:Neighbor Man;Neal Thomas:Halamer;Stephen Rutledge:Hotel Manager;Beah Richards:Drug Counselor;William S. Burroughs:Tom the Priest;Robert Lee Pitchlynn:Hotel Clerk;Roger Hancock:Machinist;Michael Parker:Crying Boy;Ray Monge:Accomplice;Doug Cooeyate:Guy with Knife (uncredited)